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Article

Human down syndrome cell adhesion molecules (DSCAMs) are functionally conserved with Drosophila Dscam[TM1] isoforms in controlling neurodevelopment.

Insect biochemistry and molecular biology - 1 Oct 2011

Huang Jianhua, Wang Ying, Raghavan Sangeetha, Feng Siqian, Kiesewetter Kurtis, Wang Jian

Abstract excerpt

Drosophila Down syndrome cell adhesion molecule (Dscam) potentially produces more than 150,000 cell adhesion molecules that share two alternative transmembrane/juxtamembrane (TM) domains, which dictate the dendrite versus axon subcellular distribution and function of different Dscam isoforms. Vertebrate genomes contain two closely related genes, DSCAM and DSCAM-Like1 (DSCAML1), which do not have extensive...

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Source

Identifiers

PMID: 21645617
DOI: 10.1016/j.ibmb.2011.05.008

Genes

DSCAM
DSCAML1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human down syndrome cell adhesion molecules (DSCAMs) are functionally conserved with Drosophila Dscam[TM1] isoforms in controlling neurodevelopment.PMID 21645617Read ↗

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Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesionSemantic proximity Read ↗

DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous systemSemantic proximity Read ↗

Intron-targeted mutagenesis reveals roles for Dscam1 RNA pairing architecture-driven splicing bias in neuronal wiring.Semantic proximity Read ↗

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