Article

<i>Dscam</i> gene triplication causes neocortical overinhibition in Down syndrome

2020-01-03

Abstract excerpt

A growing number of molecules have been identified as regulators of inhibitory synapse development, but whether dysregulated expression of these molecules contribute to brain disorders is poorly understood. Here we show that Down syndrome cell adhesion molecule ( Dscam ) regulates the inhibition of neocortical pyramidal neurons (PyNs) in a level-dependent fashion. Loss of Dscam impairs inhibitory neuron developm...

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Literature Corpus work: fa774a70-8fad-563b-8e18-03abc7b44caa
DOI: 10.1101/2020.01.03.894113

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