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Article

DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system

1 Feb 1998

Abstract excerpt

Down syndrome (DS), a major cause of mental retardation, is characterized by subtle abnormalities of cortical neuroanatomy, neurochemistry and function. Recent work has shown that chromosome band 21q22 is critical for many of the neurological phenotypes of DS. A gene, DSCAM (Down syndrome cell adhesion molecule), has now been isolated from chromosome band 21q22.2-22.3. Homology searches indicate that the putative...

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PMID: 9426258
DOI: 10.1093/hmg/7.2.227

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Related research

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DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous systemPMID 9426258Read ↗

The role of Down syndrome cell adhesion molecule in Down syndromeSemantic proximity Read ↗

Restoring DSCAM expression rescues neuronal morphology and axon guidance deficits in Down syndromeSemantic proximity Read ↗

Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder.Semantic proximity Read ↗

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity.Semantic proximity Read ↗

A novel mouse Dscam mutation inhibits localization and shedding of DSCAM.Semantic proximity Read ↗

Human down syndrome cell adhesion molecules (DSCAMs) are functionally conserved with Drosophila Dscam[TM1] isoforms in controlling neurodevelopment.Semantic proximity Read ↗

DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse modelsSemantic proximity Read ↗

A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heartSemantic proximity Read ↗

<i>Dscam</i> gene triplication causes neocortical overinhibition in Down syndromeSemantic proximity Read ↗

Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome.Semantic proximity Read ↗

A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical regionSemantic proximity Read ↗

Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesionSemantic proximity Read ↗

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