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Article

The mechanism of group I self-splicing: an internal guide sequence can be provided in trans.

The EMBO journal - 1 Jun 1990

Winter A J, Groot Koerkamp M J, Tabak H F

Abstract excerpt

We have reconstituted a group I self-splicing reaction between two RNA molecules with different functional RNA parts: a substrate molecule containing the 5' splice site and a functional internal guide sequence (IGS), and a ribozyme molecule with core structure elements and splice sites but a mutated IGS. The 5' exon of the substrate molecule is ligated in trans to the 3' exon of the ribozyme molecule, suggesting...

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Identifiers

PMID: 2189725
DOI: 10.1002/j.1460-2075.1990.tb08319.x
PMCID: PMC551900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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