Article
Sequence specificity of in vivo reverse splicing of the Tetrahymena group I intron.
RNA (New York, N.Y.) - 1 Jan 1999
Roman J, Rubin M N, Woodson S A
Abstract excerpt
Reverse splicing of group I introns is proposed to be a mechanism by which intron sequences are transferred to new genes. Integration of the Tetrahymena intron into the Escherichia coli 23S rRNA via reverse splicing depends on base pairing between the guide sequence of the intron and the target site. To investigate the substrate specificity of reverse splicing, the wild-type and 18 mutant introns with different...
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