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Article

Optimization and application of the group I ribozyme trans-splicing reaction.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2004

Einvik Christer, Fiskaa Tonje, Lundblad Eirik W, Johansen Steinar

Abstract excerpt

Group I ribozymes are naturally occurring catalytic RNAs that are able to excise themselves as introns (group I introns) from a precursor RNA, and to ligate the flanking exons. Group I ribozymes can be engineered to act in trans by recognizing a separate RNA molecule in a sequence specific manner, and to covalently link an RNA sequence to this separate RNA molecule. This ribozyme transesterification reaction has...

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Identifiers

PMID: 15017063
DOI: 10.1385/1-59259-746-7:359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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