Article
Group I-like ribozymes with a novel core organization perform obligate sequential hydrolytic cleavages at two processing sites.
RNA (New York, N.Y.) - 1 May 1998
Einvik C, Nielsen H, Westhof E, Michel F, Johansen S
Abstract excerpt
A new category of self-splicing group I introns with conserved structural organization and function is found among the eukaryotic microorganisms Didymium and Naegleria. These complex rDNA introns contain two distinct ribozymes with different functions: a regular group I splicing-ribozyme and a small internal group I-like ribozyme (GIR1), probably involved in protein expression. GIR1 was found to cleave at two...
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