Article
The spliceosome catalyzes debranching in competition with reverse of the first chemical reaction.
RNA (New York, N.Y.) - 1 Jul 2013
Tseng Chi-Kang, Cheng Soo-Chen
Abstract excerpt
Splicing of nuclear pre-mRNA occurs via two steps of the transesterification reaction, forming a lariat intermediate and product. The reactions are catalyzed by the spliceosome, a large ribonucleoprotein complex composed of five small nuclear RNAs and numerous protein factors. The spliceosome shares a similar catalytic core structure with that of fungal group II introns, which can self-splice using the same...
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