Article
Novel phenotype of C3H 10T1/2 fibroblasts cotransfected with the c-Ha-ras and adenovirus 5 E1A oncogenes.
Molecular carcinogenesis - 1 Jan 1990
Davenport E A, Taparowsky E J
Abstract excerpt
C3H 10T1/2 fibroblasts are converted to fully transformed phenotype following coexpression of an activated c-Ha-ras gene and either a constitutively expressed viral or cellular myc gene. In this report, we examined whether the early region 1A (E1A) of adenovirus 5, which synergizes with ras to convert primary embryonic cells to a transformed phenotype, can synergize with ras to transform the established mouse...
Topics
- Animals
- Cell Differentiation
- Cell Transformation, Viral
- Cells, Cultured
- Fibroblasts
- Gene Expression Regulation
- Mice
- Mice, Inbred C3H
- Oncogenes
- Phenotype
- Proto-Oncogene Proteins