Article
Overexpression of the E2F-1 transcription factor gene mediates cell transformation.
Gene expression - 1 Jan 1995
Yang X H, Sladek T L
Abstract excerpt
The E2F transcription factor can regulate expression of numerous cellular genes controlling proliferation, including proto-oncogenes and genes regulating cell cycle progression. Therefore, genes comprising the E2F gene family could potentially contribute to carcinogenesis. To test the potential o...
Topics
- 3T3 Cells
- Animals
- Binding Sites
- Carrier Proteins
- Cell Cycle Proteins
- Cell Transformation, Neoplastic
- Chloramphenicol O-Acetyltransferase
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- G1 Phase
- Genes, Reporter
- Genetic Vectors
- Humans
- Immunoblotting
- Mice
- Mice, Inbred BALB C
- Oncogenes