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Article

Overexpression of the E2F-1 transcription factor gene mediates cell transformation.

Gene expression - 1 Jan 1995

Yang X H, Sladek T L

Abstract excerpt

The E2F transcription factor can regulate expression of numerous cellular genes controlling proliferation, including proto-oncogenes and genes regulating cell cycle progression. Therefore, genes comprising the E2F gene family could potentially contribute to carcinogenesis. To test the potential of E2F to act as a transforming gene, a cDNA encoding E2F-1 was constitutively overexpressed in established rodent cells...

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Identifiers

PMID: 7787412
PMCID: PMC6134389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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