Article
Rac1 and extracellularly regulated kinase activation are sufficient for E1A-dependent cooperative transformation of primary epithelial cells, but progression can only be modulated by E1A or Rac1.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Mar 1998
Fischer R S, Zheng Y, Quinlan M P
Abstract excerpt
Ras transformation of fibroblast cell lines requires activation of multiple distinct signal pathways that act synergistically. E1A-ras cotransformation of primary epithelial cells is enhanced by distinct mutations in the second exon of E1A, resulting in "hypertransformation" and metastasis. The m...
Topics
- Actin Cytoskeleton
- Adenovirus E1A Proteins
- Adenovirus E1B Proteins
- Adenoviruses, Human
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Adhesion
- Cell Division
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Enzyme Activation
- Epithelial Cells
- Exons