Article
Wild-type adenovirus type 5 transforming genes function as transdominant suppressors of oncogenesis in mutant adenovirus type 5 transformed rat embryo fibroblast cells.
Cancer research - 15 Apr 1993
Su Z Z, Leon J A, Jiang H, Austin V N, Zimmer S G, Fisher P B
Abstract excerpt
Transformation of cloned rat embryo fibroblast (CREF) cells with the host-range adenovirus type 5 (Ad5) mutant, H5hr1, results in transformants with a fibroblastic morphology which displays a cold-sensitive transformation phenotype and oncogenic potential in both nude mice and syngeneic rats. In...
Topics
- Adenovirus E1A Proteins
- Adenoviruses, Human
- Animals
- Base Sequence
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Dexamethasone
- Genes, Tumor Suppressor
- Genes, Viral
- Killer Cells, Natural
- Mammary Tumor Virus, Mouse
- Molecular Sequence Data
- Mutation
- Oncogenes
- Polymerase Chain Reaction
- RNA, Viral
- Rats
- Rats, Sprague-Dawley