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Article

Cooperation of oncogenes in the multistep transformation of established fibroblasts in culture.

Anticancer research - 1 Jan 2000

Davenport E A, Drobes B L, Menke S L, Vaidya T B, Taparowsky E J

Abstract excerpt

The multistage nature of carcinogenesis observed in a variety of systems has been linked experimentally to the sequential activation and subsequent cooperation of oncogene proteins. Cellular transformation resulting from cooperative interactions between activated oncogenes has been described previously for cultured primary cells and certain established cell lines. Our laboratory is using the mouse embryonic cell...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Line
Cell Transformation, Neoplastic
Chromosome Deletion
DNA Transposable Elements
Fibroblasts
Genes
Genes, ras
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oncogenes

Plasmids

Transfection

Source

Identifiers

PMID: 2845855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2845855-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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