Article
"Hit-and-run" transformation by adenovirus oncogenes.
Journal of virology - 1 Apr 2001
Nevels M, Täuber B, Spruss T, Wolf H, Dobner T
Abstract excerpt
According to classical concepts of viral oncogenesis, the persistence of virus-specific oncogenes is required to maintain the transformed cellular phenotype. In contrast, the "hit-and-run" hypothesis claims that viruses can mediate cellular transformation through an initial "hit," while maintenance of the transformed state is compatible with the loss ("run") of viral molecules. It is well established that the...
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