Synergism between pairs of immortalizing genes in transformation assays of rat embryo fibroblasts.

Article

Synergism between pairs of immortalizing genes in transformation assays of rat embryo fibroblasts.

Oncogene - 1 Dec 1990

Peacock J W, Matlashewski G J, Benchimol S

Abstract excerpt

A number of cellular and viral genes encode proteins that play a role in the establishment of normal cells in culture. In addition, these genes cooperate with activated ras genes to induce cellular transformation. We show that ras-dependent transformation of rat embryo fibroblasts is more efficie...

Topics

Alleles
Animals
Cell Transformation, Neoplastic
Cells, Cultured
Embryo, Mammalian
Fibroblasts
Genes, Viral
Genes, myc
Genes, p53
Genes, ras
Genetic Complementation Test
Papillomaviridae
Phosphoproteins
Rats
Rats, Inbred F344

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