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Article

Dominant negative mutants of Myc inhibit cooperation of both Myc and adenovirus serotype-5 E1a with Ras.

Journal of cellular physiology - 1 Apr 1996

MacGregor D, Li L H, Ziff E B

Abstract excerpt

We have used dominant negative Myc mutants to analyze the Myc and E1a mechanisms of cooperation with Ras. We show that mutants of Myc with an altered basic region (BR; RR366, 367EE) or deletion of the leucine zipper (LZ; delta aa 414-439), changes which modify the DNA binding domain, or with deletions in the Myc amino terminal conserved regions box 1 (dlMB1; delta aa 46-55) and box 2 (dlMB2; delta aa 132-140)...

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PMID: 8698846
DOI: 10.1002/(SICI)1097-4652(199604)167:1<95::AID-JCP11>3.0.CO;2-O

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Source receipt: pubmed, retrieved 7 Sept 2026.

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