Article
Adenovirus E1A-p105(Rb) protein interactions play a direct role in the initiation but not the maintenance of the rodent cell transformed phenotype.
Oncogene - 1 Jun 1991
Nielsch U, Fognani C, Babiss L E
Abstract excerpt
The morphological transformation of rodent fibroblast cells by adenovirus requires expression of the viral E1A and E1B genes. Recent studies have suggested that one function of the E1A proteins is to interact with and inactivate specific cellular proteins (anti-oncoproteins) that maintain regulated cell growth. One candidate cellular protein that may be influenced by its interaction with the E1A oncoproteins is...
Topics
- Adenoviruses, Human
- Animals
- Cell Line, Transformed
- Cell Transformation, Viral
- Fibroblasts
- Gene Expression
- Genes, Viral
- Phenotype
- Precipitin Tests
- Rats
- Retinoblastoma Protein