Article
The C terminus of E1A regulates tumor progression and epithelial cell differentiation.
Virology - 30 Sept 1998
Fischer R S, Quinlan M P
Abstract excerpt
The E1A gene of adenovirus has been considered both a dominant oncogene and a tumor suppressor. It has been reported to induce epithelial cell but to prevent myoblast differentiation. E1A enables oncogenes that are unable to transform primary cells on their own to do so, yet suppresses tumor prog...
Topics
- Actins
- Adenovirus E1A Proteins
- Adenoviruses, Human
- Animals
- Cell Differentiation
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Cells, Cultured
- Epithelial Cells
- Genes, Tumor Suppressor
- Genes, Viral
- Humans
- Membrane Proteins
- Mutation
- Oncogenes
- Phosphoproteins
- Rats
- Tight Junctions