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Article

A multiparametric approach to monitor the effects of γ-secretase inhibition along the whole intestinal tract.

Disease models & mechanisms - 1 Jan 2012

Droy-Dupré Laure, Vallée Mickaël, Bossard Céline, Laboisse Christian L, Jarry Anne

Abstract excerpt

γ-secretase inhibitors (GSIs) have been recently proposed as chemopreventive agents in gastrointestinal neoplasia, because they lead, through inhibition of the Notch signaling pathway, to goblet cell conversion in some intestinal adenomas of the Apc(Min) mice, and halt epithelial cell proliferation. In this study, we examine in depth, in normal mice, the effects of a GSI, dibenzazepine (DBZ), intraperitoneally...

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Source

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Identifiers

PMID: 21885452
DOI: 10.1242/dmm.007591
PMCID: PMC3255549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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