Article

Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway

2024-01-03

Abstract excerpt

<h4>SUMMARY</h4> Cigarette smoking is a well-known risk factor inducing the development and progression of various diseases. Nicotine (NIC) is the major constituent of cigarette smoke. However, knowledge of the mechanism underlying the NIC-regulated stem cell functions is limited. In this study, we demonstrate that NIC increases the abundance and proliferative activity of intestinal stem cells (ISCs) in vivo and...

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Literature Corpus work: 379f1857-53ea-59a5-befb-45f172d298e7
DOI: 10.1101/2024.01.02.573853

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