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Article

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

Nature - 16 Jun 2005

van Es Johan H, van Gijn Marielle E, Riccio Orbicia, van den Born Maaike, Vooijs Marc, Begthel Harry, Cozijnsen Miranda, Robine Sylvie, Winton Doug J, Radtke Freddy, Clevers Hans

Abstract excerpt

The self-renewing epithelium of the small intestine is ordered into stem/progenitor crypt compartments and differentiated villus compartments. Recent evidence indicates that the Wnt cascade is the dominant force in controlling cell fate along the crypt-villus axis. Here we show a rapid, massive conversion of proliferative crypt cells into post-mitotic goblet cells after conditional removal of the common Notch...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15959515
DOI: 10.1038/nature03659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.PMID 15959515Read ↗

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A genetic study of the role of the Wnt/beta-catenin signalling in Paneth cell differentiation.Semantic proximity Read ↗

Notch inhibition counteracts Paneth cell death in absence of caspase-8.Semantic proximity Read ↗

Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling.Semantic proximity Read ↗

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formationSemantic proximity Read ↗

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal TumorigenesisSemantic proximity Read ↗

Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a γ-secretase inhibitor, in a preclinical colorectal explant modelSemantic proximity Read ↗

Notch signaling inactivation by small molecule γ-secretase inhibitors restores the multiciliated cell population in the airway epitheliumSemantic proximity Read ↗

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