Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bcl-2 is a critical mediator of intestinal transformation

9 Mar 2016

Abstract excerpt

Intestinal tumour formation is generally thought to occur following mutational events in the stem cell pool. However, active NF-κB signalling additionally facilitates malignant transformation of differentiated cells. We hypothesized that genes shared between NF-κB and intestinal stem cell (ISCs) signatures might identify common pathways that are required for malignant growth. Here, we find that the NF-κB target...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Research and Treatments
Share to Cell death mechanisms and regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26956214
DOI: 10.1038/ncomms10916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bcl-2 is a critical mediator of intestinal transformationPMID 26956214Read ↗

BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancerSemantic proximity Read ↗

IκBα deficiency imposes a fetal phenotype to intestinal stem cells.Semantic proximity Read ↗

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.Semantic proximity Read ↗

Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-βSemantic proximity Read ↗

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancerSemantic proximity Read ↗

Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury.Semantic proximity Read ↗

Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after γ-irradiation through Wnt/β-catenin pathway.Semantic proximity Read ↗

Intestinal neoplasia induced by low dietary folate is associated with altered tumor expression profiles and decreased apoptosis in mouse normal intestine.Semantic proximity Read ↗

Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation.Semantic proximity Read ↗

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.Semantic proximity Read ↗

Differential expression of bcl-2 in intestinal epithelia correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasiaSemantic proximity Read ↗

BCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.