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Article

Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin.

Science (New York, N.Y.) - 17 Nov 1995

Hermiston M L, Gordon J I

Abstract excerpt

Cadherins mediate cell adhesion and are essential for normal development. Embryonic stem cells were transfected with a dominant negative N-cadherin mutant (NCAD delta) under the control of promoters active in small intestinal epithelial cells and then introduced into C57BL/6 mouse blastocysts. Analysis of adult chimeric mice revealed that expression of NCAD delta along the entire crypt-villus axis, but not in the...

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PMID: 7502046
DOI: 10.1126/science.270.5239.1203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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