Article
Notch inhibition counteracts Paneth cell death in absence of caspase-8.
Virchows Archiv : an international journal of pathology - 1 Jul 2018
Jeon M K, Kaemmerer E, Schneider U, Schiffer M, Klaus C, Hennings J, Clahsen T, Ackerstaff T, Niggemann M, Schippers A, Longerich T, Sellge G, Trautwein C, Wagner N, Liedtke C, Gassler N
Abstract excerpt
Opposing activities of Notch and Wnt signaling regulate mucosal barrier homeostasis and differentiation of intestinal epithelial cells. Specifically, Wnt activity is essential for differentiation of secretory cells including Wnt3-producing Paneth cells, whereas Notch signaling strongly promotes generation of absorptive cells. Loss of caspase-8 in intestinal epithelium (casp8∆int) is associated with fulminant...
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