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Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis

1 Mar 2016

Abstract excerpt

OBJECTIVE: We tested the ability of Notch pathway receptors Notch1 and Notch2 to regulate stem and epithelial cell homoeostasis in mouse and human gastric antral tissue. DESIGN: Mice were treated with the pan-Notch inhibitor dibenzazepine (DBZ) or inhibitory antibodies targeting Notch1 and/or Notch2. Epithelial proliferation, apoptosis and cellular differentiation were measured by histological and molecular...

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PMID: 26933171
DOI: 10.1136/gutjnl-2015-310811

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