Article

Heterogeneity in clone dynamics within and adjacent to intestinal tumours identified by Dre-mediated lineage tracing

2020-05-14

Abstract excerpt

Somatic models of tissue pathology commonly utilise induction of gene specific mutations in mice mediated by spatiotemporal regulation of Cre recombinase. Subsequent investigation of the onset and development of disease can be limited by the inability to track changing cellular behaviours over time. Here a lineage tracing approach based on ligand dependent activation of Dre recombinase that can be employed indepen...

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Literature Corpus work: 743e2e99-a275-537d-a9ac-d3e0cc4d212b
DOI: 10.1101/2020.05.13.094284

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