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Article

Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine.

PloS one - 1 Jan 2009

Shorning Boris Y, Zabkiewicz Joanna, McCarthy Afshan, Pearson Helen B, Winton Douglas J, Sansom Owen J, Ashworth Alan, Clarke Alan R

Abstract excerpt

The Lkb1 tumour suppressor is a multitasking kinase participating in a range of physiological processes. We have determined the impact of Lkb1 deficiency on intestinal homeostasis, particularly focussing on secretory cell differentiation and development since we observe strong expression of Lkb1 in normal small intestine Paneth and goblet cells. We crossed mice bearing an Lkb1 allele flanked with LoxP sites with...

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Identifiers

PMID: 19165340
DOI: 10.1371/journal.pone.0004264
PMCID: PMC2626247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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