Article
Heterogeneity in clone dynamics within and adjacent to intestinal tumours identified by Dre-mediated lineage tracing.
Disease models & mechanisms - 1 Jan 2021
Thorsen Ann-Sofie, Khamis Doran, Kemp Richard, Colombé Mathilde, Lourenço Filipe C, Morrissey Edward, Winton Douglas
Abstract excerpt
Somatic models of tissue pathology commonly use induction of gene-specific mutations in mice mediated by spatiotemporal regulation of Cre recombinase. Subsequent investigation of the onset and development of disease can be limited by the inability to track changing cellular behaviours over time. Here, a lineage-tracing approach based on ligand-dependent activation of Dre recombinase that can be employed...
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