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Article

Metallothioneins with interdomain hinges expanded by insertion mutagenesis.

Protein engineering - 1 Jan 1990

Rhee I K, Lee K S, Huang P C

Abstract excerpt

Specific peptides of varying lengths were inserted between the two metal cluster domains of metallothionein (MT), which normally are spanned by only three amino acids, Lys-Lys-Ser. These interdomain expansions were made to test if such structural alterations would affect MT function. These constructs were engineered by inserting defined oligonucleotides of up to four tandem repeats of dodecanucleotides and...

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PMID: 2184435
DOI: 10.1093/protein/3.3.205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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