Article
Investigating the influence of histidine residues on the metal ion binding ability of the wheat metallothionein γ-Ec-1 domain.
Journal of inorganic biochemistry - 1 Dec 2015
Tarasava Katsiaryna, Freisinger Eva
Abstract excerpt
While Zn(II) and Cd(II) have similar geochemical and environmental properties, their biological properties are distinctively different as Cd(II) ions have very limited metabolic significance and are mostly even toxic, while Zn(II) ions belong to the most essential micronutrients. One of the key proteins involved in intracellular Zn(II) and Cd(II) binding are metallothioneins (MTs), small cysteine-rich proteins...
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