Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene.

doi:10.1038/308513a0

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Article

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene.

Nature - 1 Jan 2000

Karin M, Haslinger A, Holtgreve H, Richards R I, Krauter P, Westphal H M, Beato M

Abstract excerpt

Deletion experiments have defined two stretches of DNA (genetic elements), lying close to the promoter for a human gene for metallothionein, that separately mediate the induction of the gene by heavy metal ions, particularly cadmium, and by glucocorticoid hormones. The element responsible for ind...

Topics

Base Sequence
Cadmium
Chromosome Deletion
Cloning, Molecular
DNA Restriction Enzymes
Dexamethasone
Genes
Glucocorticoids
Humans
Metallothionein
Mutation
Operon
Receptors, Glucocorticoid

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