Article
Construction of alpha-alpha domains structure in recombinant monkey metallothionein-1.
Journal of inorganic biochemistry - 25 Nov 2002
Huang Zhong Xian, Gao Yuan, Yu Wen Hao, Zhang Su Yan, Yang Peng Yuan
Abstract excerpt
The differences in metal-thiolate coordination and reactivity of mammalian metallothionein (MT) domains are closely related to their distinct, highly conservative cysteine number and position. Monkey metallothionein-1, containing a beta-domain with Cd(3)S(9) cluster and an alpha-domain with Cd(4)S(11) cluster, was used to evaluate the role of cysteine residues in the formation of MT's metal-thiolate clusters. The...
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