Article
Cadmium resistance conferred to yeast by a non-metallothionein-encoding gene of the earthworm Enchytraeus.
The Journal of biological chemistry - 15 Feb 2002
Tschuschke Steffen, Schmitt-Wrede Hans-Peter, Greven Hartmut, Wunderlich Frank
Abstract excerpt
The earthworm Enchytraeus is able to survive in cadmium (Cd)-polluted environments. Upon Cd exposure, the worms express a gene encoding the putative non-metallothionein 25-kDa cysteine-rich protein (CRP), which contains eight repeats with highly conserved cysteines in Cys-X-Cys and Cys-Cys arrangements exhibiting 36-53% identities to the 6-7-kDa metallothioneins of different organisms. Here, we demonstrate that...
Topics
- Amino Acid Sequence
- Animals
- Aspartic Acid
- Blotting, Western
- Cadmium
- Cysteine
- DNA, Complementary
- Dose-Response Relationship, Drug
- Drug Resistance
- Metallothionein
- Mice
- Microscopy, Confocal
- Models, Genetic
- Molecular Sequence Data