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Finger-loops, oncogenes, and metals. Claude Passmore Brown memorial lecture.

Annals of clinical and laboratory science - 1 Jan 2000

Sunderman F W, Barber A M

Abstract excerpt

Certain DNA-binding proteins that regulate gene expression contain single or multiple copies of short polypeptide sequences, approximately 30 residues long, consisting of combinations of four Cys or His residues at defined spacing, so that Zn++ is complexed in tetrahedral coordination with the respective thiol-sulfur and/or imidazole-nitrogen atoms. The Zn++ ion evidently serves as a strut that stabilizes folding...

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PMID: 2841900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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