Article
Finger-loops, oncogenes, and metals. Claude Passmore Brown memorial lecture.
Annals of clinical and laboratory science - 1 Jan 2000
Sunderman F W, Barber A M
Abstract excerpt
Certain DNA-binding proteins that regulate gene expression contain single or multiple copies of short polypeptide sequences, approximately 30 residues long, consisting of combinations of four Cys or His residues at defined spacing, so that Zn++ is complexed in tetrahedral coordination with the re...
Topics
- Amino Acid Sequence
- Animals
- Cadmium
- Cobalt
- DNA-Binding Proteins
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Oncogenes
- Protein Conformation
- Protein Kinases
- Receptors, Cell Surface