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Article

A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression.

PLoS genetics - 1 Jul 2011

Meyer Kerstin B, Maia Ana-Teresa, O'Reilly Martin, Ghoussaini Maya, Prathalingam Radhika, Porter-Gill Patricia, Ambs Stefan, Prokunina-Olsson Ludmila, Carroll Jason, Ponder Bruce A J

Abstract excerpt

Genetic mapping studies have identified multiple cancer susceptibility regions at chromosome 8q24, upstream of the MYC oncogene. MYC has been widely presumed as the regulated target gene, but definitive evidence functionally linking these cancer regions with MYC has been difficult to obtain. Here we examined candidate functional variants of a haplotype block at 8q24 encompassing the two independent risk alleles...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21814516
DOI: 10.1371/journal.pgen.1002165
PMCID: PMC3140991

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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