Article
A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer.
Nature communications - 17 Jul 2020
Walavalkar Kaivalya, Saravanan Bharath, Singh Anurag Kumar, Jayani Ranveer Singh, Nair Ashwin, Farooq Umer, Islam Zubairul, Soota Deepanshu, Mann Rajat, Shivaprasad Padubidri V, Freedman Matthew L, Sabarinathan Radhakrishnan, Haiman Christopher A, Notani Dimple
Abstract excerpt
Genetic variation at the 8q24 locus is linked with the greater susceptibility to prostate cancer in men of African ancestry. One such African ancestry specific rare variant, rs72725854 (A>G/T) (~6% allele frequency) has been associated with a ~2-fold increase in prostate cancer risk. However, the functional relevance of this variant is unknown. Here we show that the variant rs72725854 is present in a prostate...
Read the complete abstract on PubMed