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Article

Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition.

International journal of molecular sciences - 16 Aug 2021

Ren Naixia, Liu Qingqing, Yan Lingjie, Huang Qilai

Abstract excerpt

Functional characterization of cancer risk-associated single nucleotide polymorphism (SNP) identified by genome-wide association studies (GWAS) has become a big challenge. To identify the regulatory risk SNPs that can lead to transcriptional misregulation, we performed parallel reporter gene assays with both alleles of 213 prostate cancer risk-associated GWAS SNPs in 22Rv1 cells. We disclosed 32 regulatory SNPs...

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Share to Chromatin
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Minor Histocompatibility Antigens

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Share to Ribonucleoproteins, Small Nuclear

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Source

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Identifiers

PMID: 34445492
DOI: 10.3390/ijms22168792
PMCID: PMC8395720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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