Article
Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility.
BMC genomics - 11 Jan 2008
Solé Xavier, Hernández Pilar, de Heredia Miguel López, Armengol Lluís, Rodríguez-Santiago Benjamín, Gómez Laia, Maxwell Christopher A, Aguiló Fernando, Condom Enric, Abril Jesús, Pérez-Jurado Luis, Estivill Xavier, Nunes Virginia, Capellá Gabriel, Gruber Stephen B, Moreno Víctor, Pujana Miguel Angel
Abstract excerpt
BACKGROUND: Germline genetic variation is associated with the differential expression of many human genes. The phenotypic effects of this type of variation may be important when considering susceptibility to common genetic diseases. Three regions at 8q24 have recently been identified to independently confer risk of prostate cancer. Variation at 8q24 has also recently been associated with risk of breast and...
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