Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel role of prostate cancer risk variant rs7247241 on PPP1R14A isoform transition through allelic TF binding and CpG methylation.

Human molecular genetics - 19 May 2022

Tian Yijun, Soupir Alex, Liu Qian, Wu Lang, Huang Chiang-Ching, Park Jong Y, Wang Liang

Abstract excerpt

Although previous studies identified numerous single nucleotide polymorphisms (SNPs) and their target genes predisposed to prostate cancer (PrCa) risks, SNP-related splicing associations are rarely reported. In this study, we applied distance-based sQTL analysis (sQTLseekeR) using RNA-seq and SNP genotype data from benign prostate tissue (n = 467) and identified significant associations in 3344 SNP-transcript...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Intracellular Signaling Peptides and Proteins

Share to Muscle Proteins

Share to Prostatic Neoplasms

Share to Protein Isoforms

Share to RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 34849858
DOI: 10.1093/hmg/ddab347
PMCID: PMC9122641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel role of prostate cancer risk variant rs7247241 on PPP1R14A isoform transition through allelic TF binding and CpG methylation.PMID 34849858Read ↗

Association of prostate cancer risk variants with gene expression in normal and tumor tissue.Semantic proximity Read ↗

Identification of Candidate mRNA Isoforms for Prostate Cancer-Risk SNPs Utilizing Iso-eQTL and sQTL Methods.Semantic proximity Read ↗

Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19.Semantic proximity Read ↗

Novel prostate cancer susceptibility gene SP6 predisposes patients to aggressive disease.Semantic proximity Read ↗

A Splicing Transcriptome-Wide Association Study Identifies Candidate Altered Splicing for Prostate Cancer Risk.Semantic proximity Read ↗

Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition.Semantic proximity Read ↗

Common genetic variants in the PSCA gene influence gene expression and bladder cancer risk.Semantic proximity Read ↗

Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.Semantic proximity Read ↗

Identification and validation of regulatory SNPs that modulate transcription factor chromatin binding and gene expression in prostate cancer.Semantic proximity Read ↗

A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression.Semantic proximity Read ↗

Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.Semantic proximity Read ↗

Identification of candidate genes for prostate cancer-risk SNPs utilizing a normal prostate tissue eQTL data set.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.