Article
Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.
Human genetics - 1 Sept 2008
Yeager Meredith, Xiao Nianqing, Hayes Richard B, Bouffard Pascal, Desany Brian, Burdett Laura, Orr Nick, Matthews Casey, Qi Liqun, Crenshaw Andrew, Markovic Zdenek, Fredrikson Karin M, Jacobs Kevin B, Amundadottir Laufey, Jarvie Thomas P, Hunter David J, Hoover Robert, Thomas Gilles, Harkins Timothy T, Chanock Stephen J
Abstract excerpt
Recently, genome-wide association studies have identified loci across a segment of chromosome 8q24 (128,100,000-128,700,000) associated with the risk of breast, colon and prostate cancers. At least three regions of 8q24 have been independently associated with prostate cancer risk; the most centromeric of which appears to be population specific. Haplotypes in two contiguous but independent loci, marked by...
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