Article
Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome.
Human molecular genetics - 1 Jan 2015
Du Meijun, Yuan Tiezheng, Schilter Kala F, Dittmar Rachel L, Mackinnon Alexander, Huang Xiaoyi, Tschannen Michael, Worthey Elizabeth, Jacob Howard, Xia Shu, Gao Jianzhong, Tillmans Lori, Lu Yan, Liu Pengyuan, Thibodeau Stephen N, Wang Liang
Abstract excerpt
Chromosome 8q24 locus contains regulatory variants that modulate genetic risk to various cancers including prostate cancer (PC). However, the biological mechanism underlying this regulation is not well understood. Here, we developed a chromosome conformation capture (3C)-based multi-target sequencing technology and systematically examined three PC risk regions at the 8q24 locus and their potential regulatory...
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