Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive functional annotation of 77 prostate cancer risk loci.

PLoS genetics - 1 Jan 2014

Hazelett Dennis J, Rhie Suhn Kyong, Gaddis Malaina, Yan Chunli, Lakeland Daniel L, Coetzee Simon G, Henderson Brian E, Noushmehr Houtan, Cozen Wendy, Kote-Jarai Zsofia, Eeles Rosalind A, Easton Douglas F, Haiman Christopher A, Lu Wange, Farnham Peggy J, Coetzee Gerhard A

Abstract excerpt

Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics, but the causal links between increased genetic risk and onset/progression of disease processes remain to be identified. Here we report the first step in such an endeavor for prostate cancer. We provide a comprehensive annotation of the 77 known risk loci, based upon highly correlated variants in biologically relevant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Linkage Disequilibrium

Share to Molecular Sequence Annotation

Share to Oligonucleotide Array Sequence Analysis

Share to Prostatic Neoplasms

Share to Response Elements

Source

Open in PubMed Open full text

Identifiers

PMID: 24497837
DOI: 10.1371/journal.pgen.1004102
PMCID: PMC3907334

Genes

JAZF1
NUDT11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive functional annotation of 77 prostate cancer risk loci.PMID 24497837Read ↗

Systematic enrichment analysis of potentially functional regions for 103 prostate cancer risk-associated loci.Semantic proximity Read ↗

Gene regulatory mechanisms underpinning prostate cancer susceptibility.Semantic proximity Read ↗

Mechanistic insights into genetic susceptibility to prostate cancer.Semantic proximity Read ↗

In silico functional pathway annotation of 86 established prostate cancer risk variants.Semantic proximity Read ↗

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.Semantic proximity Read ↗

Functional annotation of risk loci identified through genome-wide association studies for prostate cancer.Semantic proximity Read ↗

Chromatin interactions and candidate genes at ten prostate cancer risk loci.Semantic proximity Read ↗

Allele-specific epigenetic activity in prostate cancer and normal prostate tissue implicates prostate cancer risk mechanisms.Semantic proximity Read ↗

A Large-Scale Association Study Detects Novel Rare Variants, Risk Genes, Functional Elements, and Polygenic Architecture of Prostate Cancer Susceptibility.Semantic proximity Read ↗

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.Semantic proximity Read ↗

Allele-specific epigenetic activity in prostate cancer and normal prostate tissue implicates prostate cancer risk mechanismsSemantic proximity Read ↗

Enhancer RNA transcriptome-wide association study reveals an atlas of pan-cancer susceptibility eRNAsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.