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Article

Switching the microglial harmful phenotype promotes lifelong restoration of subtantia nigra dopaminergic neurons from inflammatory neurodegeneration in aged mice.

Rejuvenation research - 1 Aug 2011

L'episcopo Francesca, Tirolo Cataldo, Testa Nunzio, Caniglia Salvatore, Morale Maria Concetta, Impagnatiello Francesco, Marchetti Bianca

Abstract excerpt

Aging represents a major risk factor for the development and progression of Parkinson disease (PD), a chronic degenerative disorder characterized by the selective loss of dopaminergic (DAergic) neurons in the subtantia nigra pars compacta (SNpc). Emerging evidence highlights the glia as a pivotal factor in PD etiology, and epidemiological studies indicate that certain nonsteroidal antiinflammatory drugs (NSAIDs)...

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PMID: 21793734
DOI: 10.1089/rej.2010.1134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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