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Article

18β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype.

Psychopharmacology - 1 Sept 2023

Luo Hanyue, Zhang Caishi, He Lujuan, Lin Zefang, Zhang Ji-Chun, Qi Qi, Chen Jia-Xu, Yao Wei

Abstract excerpt

RATIONALE: 18β-glycyrrhetinic acid (18β-GA) has been reported to have anti-inflammatory and neuroprotective effects. However, the therapeutic effect of 18β-GA in Parkinson's disease (PD) has not been defined. OBJECTIVE: The current study aimed to evaluate the potential therapeutic effects of 18β-GA in treating PD by mitigating 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. RESULTS: The...

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PMID: 37436491
DOI: 10.1007/s00213-023-06415-6

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