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Article

Rg1 improves LPS-induced Parkinsonian symptoms in mice via inhibition of NF-κB signaling and modulation of M1/M2 polarization.

Acta pharmacologica Sinica - 1 Apr 2020

Liu Jia-Qi, Zhao Ming, Zhang Zhao, Cui Li-Yuan, Zhou Xin, Zhang Wei, Chu Shi-Feng, Zhang Da-Yong, Chen Nai-Hong

Abstract excerpt

Ginsenoside Rg1 is one of the most active ingredients in ginseng, which has been reported to protect dopaminergic neurons and improve behavioral defects in MPTP model, 6-OHDA model and rotenone model. However, it is unclear whether Rg1 exerted neuroprotection in LPS-induced sub-acute PD model. In this study, we investigated the neuroprotective effect of Rg1 in the sub-acute PD mouse model and explored the related...

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Identifiers

PMID: 32203085
DOI: 10.1038/s41401-020-0358-x
PMCID: PMC7468333

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