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Article

Remodeling microglia to a protective phenotype in Parkinson's disease?

Neuroscience letters - 14 Sept 2020

Awogbindin Ifeoluwa Oluleke, Ishola Ismail Ogunbayode, St-Pierre Marie-Kim, Carrier Micaël, Savage Julie C, Di Paolo Thérèse, Tremblay Marie-Ève

Abstract excerpt

Parkinson's disease (PD) is the most widespread movement disorder with a prevalence of 1 in 1000 individuals above 60 years of age. Until now, understanding the pathological mechanisms of PD to translate them into therapy has remained a high research priority. In this review, we highlight evidence describing the involvement of microglial dysfunction in PD. Thereafter, we provide current knowledge suggesting that...

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Identifiers

PMID: 32561452
DOI: 10.1016/j.neulet.2020.135164

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