Article

Aged-Related Changes in Microglia and Neurodegenerative Diseases: Exploring the Connection

2024-05-13

Abstract excerpt

Microglial cells are brain macrophages that support and protect the central nervous system enviroment. Aging induces alterations in microglial polarization, resulting in a shift towards a neurotoxic phenotype characterized by increased expression of pro-inflammatory markers. Dysregulation of microglial cells regulatory pathways and interactions with neurons contribute to chronic activation and neurodegeneration. A...

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Literature Corpus work: f40e1d27-1fce-5852-abf2-287b8d97e4a6
DOI: 10.20944/preprints202405.0722.v1

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