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Article

IFNγ alters the aberrant phenotype of α-synuclein-treated microglia reducing the detrimental impact of their secretome on dopaminergic neurons.

Neuroscience - 25 May 2026

Niskanen Jonna, Hakosalo Vili, Hämäläinen Wilhelmiina, Kälvälä Sara, Hyvönen Mervi T, Zhang Yinjia, Luk Kelvin C, Koistinaho Jari, Lehtonen Marko, Goldsteins Gundars, Albert Katrina, Lehtonen Šárka

Abstract excerpt

Microglia play a major role in the pathophysiology of Parkinson's disease, where they regulate both α-synuclein (αSyn) aggregate clearance and inflammatory responses. Interferon gamma (IFNγ) is a strong immunomodulator, but its role in shaping human microglial phenotypes during αSyn exposure remains incompletely understood. Further, whether the secreted factors from microglia after exposure to αSyn pre-formed...

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PMID: 41912064
DOI: 10.1016/j.neuroscience.2026.03.040

Genes

FOS
TGM2
TH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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