Article

Microglia depletion prior to lipopolysaccharide and paraquat treatment differentially modulates behavioral and neuronal outcomes in wild type and G2019S LRRK2 knock-in mice.

2019-12-03

Abstract excerpt

<h4>Background: </h4> Substantial data have implicated microglial-driven neuroinflammation in Parkinson’s disease (PD) and environmental toxicants have been long expected as triggers of such inflammatory processes. Of course, these environmental insults act in the context of genetic vulnerability factors and in this regard, leucine rich repeat kinase 2 (LRRK2), may play a prominent role. <h4>Methods:</h4> We used...

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Literature Corpus work: 19f33746-9a72-57dd-a600-083b127b43e7
DOI: 10.21203/rs.2.17966/v1

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