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Article

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

The EMBO journal - 1 Dec 1990

Margolis B, Li N, Koch A, Mohammadi M, Hurwitz D R, Zilberstein A, Ullrich A, Pawson T, Schlessinger J

Abstract excerpt

Phospholipase C-gamma (PLC-gamma) and GTPase activating protein (GAP) are substrates of EGF, PDGF and other growth factor receptors. Since either PLC-gamma or GAP also bind to the activated receptors it was suggested that their SH2 domains are mediating this association. We attempted to delineate the specific region of the EGF receptor that is responsible for the binding, utilizing EGF receptor mutants,...

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Source

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Identifiers

PMID: 2176151
DOI: 10.1002/j.1460-2075.1990.tb07887.x
PMCID: PMC552227

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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